Final Exam

Instruction for Submission:  

1. Submit your answers in one Microsoft Word document
2. Submit you answers in Blackboard.

Question 1: Using the attached sensitivity and specificity estimates for Charlson and MM Index, create two receiver operating curve on the same chart.  Label the X-axis and Y-axis.  Provide a legend inside the plot area.  Calculate area under the curve for each curve.  Which index is more accurate?

Charlson		MM Index
Sensitivity	Specificity	Sensitivity	Specificity
0	1	0	1
0.017	1.000	0.001	1.000
0.038	1.000	0.061	0.994
0.099	1.000	0.204	0.975
0.232	0.997	0.487	0.920
0.435	0.971	0.867	0.739
0.748	0.801	0.938	0.620
0.818	0.653	0.988	0.366
0.818	0.653	0.998	0.110
0.818	0.653	1.000	0.006
0.818	0.653	1.000	0.001
0.818	0.653	1	0
1	0	1	0

 

Question 2: Score the Multi-Morbidity index using ontological adjustments for rare diagnosis with less than 30 cases. Report the likelihood ratios associated with top 20 diagnoses

• Massive data Download►  

Question 3:  In the body system model developed in the course, break cardiovascular illness into the following additional 9 systems:

• 1 Acute rheumatic fever (390–392)
• 2 Chronic rheumatic heart disease (393–398)
• 3 Hypertensive disease (401–405)
• 4 Ischemic heart disease (410–414)
• 5 Diseases of pulmonary circulation (415–417)
• 6 Other forms of heart disease (420–429)
• 7 Cerebrovascular disease (430–438)
• 8 Diseases of arteries, arterioles, and capillaries (440–449)
• 9 Diseases of veins and lymphatics, and other diseases of circulatory system(451–459)

Using the above body systems and the original list of non-cardiovascular body systems, to predict prognosis of the patient for mortality in 6 months.  Report the area under the receiver operating curve for the new body system predictions.